Biopatch™ or Kendall™ AMD Foam Disc to reduce the incidence of Central-Line-Associated Blood Stream Infection: A feasibility study

Joan Webster 1,2, Nicole Marsh 1,2, Emily Larsen 1,2, Md Abu Choudhury 2,3, Nicole Gavin 1,2, Catriona Booker 1, David Paterson 3

Royal Brisbane and Women’s Hospital, Herston, QLD, Australia

Menzies Health Institute, Griffith University, Nathan, QLD, Australia

University of Queensland, Herston, QLD, Australia

 

Introduction:
Chlorhexidine impregnated discs (Biopatch™) have been recommended to prevent central line associated blood stream infection (CLABSI). A new product Kendall™ AMD Foam Disc® is being marketed for the same purpose but the product is less expensive than Biopatch™. These products are yet to be tested in head to head comparisons with any other antimicrobial disc. The aims of this study were to test the safety of Kendall™ AMD Foam Disc® and to assess the feasibility of conducting a suitably powered trial comparing the effectiveness of the products to prevent CLABSI.

Methods:
We conducted a single-centre, pilot study where non-ICU patients requiring a PICC line were randomly allocated to either a Biopatch™ or Kendall™ group. The safety outcome was any disc-related adverse event and the feasibility outcomes were 1) ≥ 80% of eligible participants will agree to enrol; 2) ≥ 95% of participants will receive prescribed intervention; 3) < 5% of patients will be lost to follow up. We also documented any incidence of CLABSI and measured skin colonisation under the discs.

Results:
92 patients were recruited. Five (5.4%) patients refused participation; 14 (15.2%) protocol breaches occurred and no patients were lost to follow-up. Five positive blood cultures were reported (two were likely contaminants, one in each study arm). Of the remaining three cultures, one was in the Biopatch™ and two in the Kendall™ group.

Conclusion:
Kendall™ AMD Foam Disc® is safe to use for skin disinfection and feasibility to conduct an adequately powered trial has been established.

About the College

The ACIPC is the peak body for Infection Prevention and Control professionals in the Australasian region. Our stated vision is the prevention and control of infection in our communities. We commenced in January 2012 bringing together the various State and Territory infection control associations formerly in AICA (The Australian Infection Control Association) to support and encourage collaboration across Australasia.

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